In our life, there are always a variety of diseases.Most of the time we have nothing to do with the disease.Do you know Parkinson’s disease?How much do you know?
In most individuals, Parkinson’s disease is idiopathic, which means that it arises sporadically with no known cause. However, some of individuals diagnosed with Parkinsons also have family members with the disease.
Parkinson’s disease (PD) is a neurological condition related to the death of specific brain cells, including cells that control movement, mood, sleep and cognition. The symptoms, which include tremors, slowness of movement, stiffness or rigidity, sleep disorders, loss of the sense of smell, depression, and cognitive dysfunction, can appear in people as young as their thirties, but more commonly appear around the age of 60. It is estimated that the disease touches more than one in 50 people in this age group.
The motor symptoms of Parkinson’s disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. The causes of this cell death are poorly understood
Currently, diagnosis of PD can only be established through an analysis of medical history and a neurological examination by a clinician with expertise in movement disorders — no objective test for the disease exists. As the symptoms of PD often resemble those of other neurological disorders, the rate of misdiagnosis can be as high as 25 per cent, which causes distress in patients. It also creates a challenge for researchers as the data collected in clinical studies can become compromised by misdiagnosis in their pool of subjects.
The new criteria gathered knowledge and data from movement disorder experts around the world to create the most comprehensive diagnostic criteria ever developed for the disease, with the aim of improving and broadening diagnosis and treatment of the disease, especially in the early stages.
“In light of the latest scientific insights and technological advances, we were able to establish a new list of criteria based on expert clinical diagnosis,” says Dr. Ron Postuma, co-Chair of the MDS task force, who is also a researcher in neurosciences at the Research Institute of the McGill University Health Centre and at The Neuro, and associate professor in the Department of Neurology and Neurosurgery at McGill University. “Our aim was to create a benchmark that will systematize the diagnostic process, make it reproducible across centers and that will enable a wider range of non PD-specialized clinicians to provide patients with an accurate diagnosis.”
“These criteria accent how Parkinson’s disease is much more than a simple motor disorder, now incorporating motor and non-motor symptoms as well as the genetic component in some forms of PD,” adds Dr. Daniela Berg, Chair of the MDS task force and Associate Professor at the University of Tübingen, Germany.
The research team is proposing a new stage classification of the disorder with the aim of focusing attention on the early stages of PD. “With this new classification our goal is to set up a research agenda that will help identify the features that signal the presence of the disease early on,” explains Dr. Postuma. “Our hope is that, as research advances, our understanding of the mechanisms at play in the disorder will enable us to develop therapies and treatments that can be administered early in this process, eventually slowing or stopping the progression of PD altogether.”
You must be know the treatments of Parkinson’s disease.