According to the relevant agencies investigation it found that the chances of people suffering of colorectal cancer is influenced by the hormone. And oophorectomy alter the endogenous levels of sex hormones, but the impact of oophorectomy on risk of colorectal cancer is unknown. So this study because of benign disease ovariectomized postoperative patients with colorectal cancer risk aims to explore.
The researchers included 1965 patients from the Swedish registry – 2011 years ovariectomized female patients. Calculated and compared with the general population of the present study the incidence of colorectal cancer standard risk and 95% confidence intervals. Based on unilateral and bilateral oophorectomy, and whether the removal of the ovaries hysterectomy stratified. To assess the hazard ratio associated with the use of three kinds of oophorectomy and colorectal cancer risk between the Cox proportional hazards regression model to calculate 95% confidence intervals.
Results A total of 195,973 ovariectomized female patients, of colorectal cancer occurred (median follow-up time of 18 years) 3150 patients in the future. Compared with the general population, the risk of colorectal cancer patients with an increased oophorectomy. Young ovariectomized lower risk of colorectal cancer. The highest risk is in line oophorectomy 1–4 years. Women multivariate analysis, the risk of developing bilateral oophorectomy than female colorectal unilateral oophorectomy high.
In summary, the results of this study showed that the risk of oophorectomy may increase colorectal cancer.