Nat Genet: GWAS Analysis Found a New Variation to Increase the Risk of Endometrial Cancer

7 May

A recent discovery of international cooperation may increase the risk of endometrial cancer risk of women’s five new gene regions, endometrial cancer affecting women is a common type of cancer, the study will increase associated with the disease gene region known to nine.
Endometrial cancer
Endometrial cancer is cancer occurs in the uterine wall, in the UK there are about 9,000 people newly diagnosed with the disease for a year. Researchers from the University of Cambridge Research Unit, University of Oxford for over 7000 sick women and about 37,000 healthy women were studied DNA, the genetic variation found and risks related to the occurrence of the disease. Research results were published in international journals Nature Genetics.

The researchers said: “This study helps us to further delineate the cause of women suffering from endometrial cancer, genetic factors, especially for those without a family history of women before this study, we only know of four possible increased cancer risk. genomic regions.

In this study, we found five new regions, which will total to nine. This is very important for us to further understand the genetic drivers of endometrial cancer is. Interestingly, some of the genetic region we found in this study before some studies were found with ovarian cancer, the risk of prostate cancer and other types of cancer. Although the total number of each individual variation will only increase about 10% to 15% of the risk, but the real significance lies in the future of this type can be obtained by detecting the variation of genetic women combined with other risk factors to predict the risk of endometrial cancer risks, so that they can carry out routine testing, early symptoms of cancer be vigilant. ”

The study also explored these genetic variants increase the risk of cancer of the possible reasons for the treatment of endometrial cancer has prompted some significance. For example, you can filter to see if there is already marketed drugs capable of targeting these risk genes. The study found that genetic variation could help doctors detect cancer women at high risk for endometrial cancer prevention and treatment is of great significance.