CNIC’s researchers have identified how two proteins control heart growth and adaptation of hypertension. Principal investigator Dr. Guadalupe Sabio in Nature Communications explains findings, not only strengthens our cardiac cell growth and adapt to the understanding of hypertension, but also help design new strategic approach to the treatment of cardiac cause overgrowth of cardiac insufficiency . The study by Dr. Sabio and CNIC researcher Bárbara Gonzalez-Terán embodiment, the first time that the two proteins -p38γ and p38δ, control heart growth.
The heart adapts to the changing needs of each stage of life by adjusting its size. In this way the heart grows in line with the rest of our body, including during pregnancy, in a process called cardiac hypertrohpy. However, excessive physical exercise, hypertension, and obesity can trigger excessive heart growth (pathological hypertrophy), a situation that can lead to a heart attack. Understanding the molecular processes that regulate heart function and growth is therefore of immense importance.
Dr. Sabio’s group has found that p38 gamma and p38 delta regulate the growth of the left ventricle, the largest and strongest heart chamber, responsible for pumping oxygenated blood to the body. The research team showed that the hearts of mice lacking these proteins are smaller than normal. These hearts, although they function normally, are incapable of responding to external stimuli, such as high blood pressure.
The discovery advances understanding of the mechanisms through which heart cells grow and adapt. Moreover, as Dr. Sabio explains, “this new information could help in the design of new strategies to combat heart conditions caused by anomalous growth of heart muscle.”
To date, the only way to prevent excessive heart growth has been to control blood pressure. The identification of the genes that control cardiac hypertrophy will increase understanding of the shared features of cardiac disease and the normal adaptation and grow of the heart according to the physiological needs of the organism.