Chemotherapy is one of the standard treatments for prostate cancer, the tumor cell receptor as a target for prostate cancer treatment. However, prostate cancer has a resistance to the drug will play a role during chemotherapy, which greatly affected the results of chemotherapy as an anticancer agent. University of Missouri researchers drug molecules of a kind used for lipid-lowering after the initial study found that not only can stop the progression of prostate cancer, and can kill cancer cells.
“Cholesterol molecules in animal cells are present in large amounts, it is involved in the cell membrane constitutes tumor cells during the growth process will be a lot of cholesterol synthesis.” Professor Salman Hyder said, “Typically, chemotherapy, cancer patients have conducted side effects; in our experiments, we focus on the production of cholesterol lowering cancer cells, which kill cancer cells, but does not receive toxic side effects of traditional chemotherapy drugs. ”
Currently, the preferred treatment for prostate cancer include exposure to systemic chemotherapy, androgen receptors on tumor cells as targets. Growth of tumor cells often associated with hormone-related, such as testosterone. Anti-hormonal therapy or called chemical castration also often used for treatment of prostate cancer.
“Tumor cells may initially respond to these treatments are, but most of the tumor cells eventually get uncomfortable, which makes prostate cancer can continue to grow and spread.” Hyder said, “will be converted into cholesterol after hormone into tumor cells, these cholesterol synthesis pathway is quite attractive therapeutic target for prostate cancer.
Application of a originally developed for the treatment of high cholesterol molecule called RO 48-8071 of, Hyder and his research team found that this molecule can slow the growth of prostate cancer. Follow-up studies have also found that this molecule can cause tumor cell death.
With the help of these conclusions under, Hyder and his team began employing prostate cancer cells in mice to be tested. After injection of these molecules drugs, Hyder found that these molecules can indeed effectively slow tumor growth.
These findings remind us that this potential cholesterol drug is enormous, especially in that after conventional chemotherapy drugs in combination, you can explore new ways to treat prostate cancer.